Evaluation of a Protocol for fMRI Assessment Associated with Augmented Reality Rehabilitation of Stroke Subjects

Gilda Assis, Alexandre Brandao, Ana Grasielle Dionísio Correa, Gabriela Castellano


New technologies for rehabilitation involving Augmented Reality (AR) as a complement to conventional therapy have appeared in recent years. An earlier study for shoulder rehabilitation using the AR NeuroR computer system showed improved clinical outcomes for stroke patients. This study aims to analyze a proposed protocol to measure possible changes in functional brain connectivity associated with the use of the NeuroR system in the context of shoulder motor rehabilitation of post-stroke subjects. A pilot study was conducted with a poststroke patient, using resting-state functional magnetic resonance imaging (RS-fMRI). RS-fMRI signals were acquired pre and post use of the NeuroR system (pre-test and post-test), integrated into the patient’s rehabilitation program. Functional connectivity analysis of RS-fMRI was performed using the motor area as seed. The maximum connectivity value in the pre-test occurred in the ipsilesional parietal region while the maximum in the post-test was located in the ipsilesional frontal region. It was observed that the regions strongly associated with motor activity had higher connectivity values at post-test compared to pre-test. The proposed protocol is suitable and safe for verifying if functional brain connectivity was changed after the rehabilitation program with NeuroR training, indicating a possible neuroplasticity effect. Tests with a larger number of patients are still necessary.


Augmented Reality, Motor rehabilitation, Stroke

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