Hepcidin serum levels in HCV chronically mono-infected naïve patients, compared to healthy individuals

Autores

  • Ari Ben Hur Stefani Leao Hospital de Clínicas de Porto Alegre
  • Maria da Graça Ferronato Pós-Graduação em Gastroenterologia e Hepatologia, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS). Porto Alegre, RS, Brasil
  • Carlos Kupski Departamento de Gastroenterologia e Endoscopia, Hospital São Lucas, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brasil.
  • Fernando Comunello Schacher Departamento de Gastroenterologia e Endoscopia, Hospital São Lucas, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brasil. http://orcid.org/0000-0002-6991-1174
  • Denise Cantarelli Machado Laboratório de biologia celular e molecular, Instituto de Pesquisa Biomédica, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS). Porto Alegre, RS, Brasil
  • Mario Reis Álvares-da-Silva Pós-Graduação em Gastroenterologia e Hepatologia, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS). Porto Alegre, RS, Brasil Departamento de Hepatologia, Hospital de Clínicas de Porto Alegre (HCPA). Porto Alegre, RS, Brasil

Palavras-chave:

Hepcidin, HCV, interleukin-6 (IL-6), mono-infected

Resumo

Introduction: Metabolism of iron is altered in patients infected with chronically Hepatitis C. The aim of this study is to compare compare the hepcidin levels in between individuais chronically infected with HCV and uninfected individuals. The aim of this study is to compare the hepcidin serum levels between individuals chronically infected with HCV and uninfected individuals.

Methods: A cross-sectional study evaluating hepcidin serum levels of mono-infected HCV (n=29), naive, non-diabetic, non-cirrhotic and non-obese patients by means of ELISA, compared to uninfected patients (n=9) with the same characteristics. The degree of liver fibrosis, according to the METAVIR scale on liver biopsies, the lipid profile, the resistance insulin level, as calculated on HOMA-IR (homeostatic model assessment for insulin resistance), the interleukin-6 (IL-6) and the ferritin serum levels were also measured.

Results: The levels of hepcidin were significantly lower in HCV patients compared to controls (8.4 pg/mL (±4.94) vs. 19.51 pg/mL (±5.51)) with p<0.001. The levels of ferritin and hepcidin did not show any relation. There was no difference between hepcidin levels in relation to viral genotype, viral load, IL-6 and degrees of fibrosis within HCV infected individuals.

Conclusion: It is possible that hepatic iron overload in this population is explained by suppressed levels of hepcidin in patients with HCV.

Keywords: Hepcidin; HCV; interleukin-6 (IL-6); mono-infected

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Biografia do Autor

Ari Ben Hur Stefani Leao, Hospital de Clínicas de Porto Alegre

Médico residente do serviço de Medicina Interna do Hospital de Clínicas de Porto Alegre

Denise Cantarelli Machado, Laboratório de biologia celular e molecular, Instituto de Pesquisa Biomédica, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS). Porto Alegre, RS, Brasil

Laboratório de  biologia celular e molecular, Instituto de Pesquisa Biomédica

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Publicado

2018-07-19

Como Citar

1.
Leao ABHS, Ferronato M da G, Kupski C, Schacher FC, Machado DC, Álvares-da-Silva MR. Hepcidin serum levels in HCV chronically mono-infected naïve patients, compared to healthy individuals. Clin Biomed Res [Internet]. 19º de julho de 2018 [citado 29º de novembro de 2022];38(2). Disponível em: https://www.seer.ufrgs.br/index.php/hcpa/article/view/77856

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