Diagnosis of Disseminated Toxoplasmosis by Bronchoalveolar Lavage PCR in a Patient with AIDS

Authors

  • Jose Miguel Dora Hospital de Clínicas de Porto Alegre, RS
  • Guilherme Geib Hospital de Clínicas de Porto Alegre, RS
  • Fernanda de-Paris Hospital de Clínicas de Porto Alegre
  • Alice Beatriz Machado Hospital de Clínicas de Porto Alegre, RS
  • Tania Weber Furlanetto Hospital de Clínicas de Porto Alegre, RS
  • Carolina Fischinger Moura de Souza Hospital de Clínicas de Porto Alegre, RS
  • Rodrigo Pires dos Santos Hospital de Clínicas de Porto Alegre, RS

Keywords:

PCR, HIV, AIDS, toxoplasmosis, disseminated toxoplasmosis

Abstract

Pulmonary toxoplasmosis is a challenging diagnosis in immunosuppressed patients with nonspecific clinical picture and radiologic findings. We present a case of pneumonia due to Toxoplasma gondii diagnosed by polymerase chain reaction (PCR) in the bronchoalveolar lavage (BAL) fluid of a patient with acquired immunodeficiency syndrome (AIDS). Coinfection with Pneumocystis jirovecii was found in the same specimen. Direct examination and culture for bacteria, mycobacteria and other fungus were negative. Despite the intensive management, respiratory compromise evolved rapidly, with the need for ventilatory support. Acute respiratory distress syndrome developed, and the patient died of multiple organ failure. This case illustrates that a high index of suspicion is necessary for diagnosis of pulmonary toxoplasmosis, a potentially fatal condition. Due to high diagnostic performance, PCR in BAL fluid should be included in the evaluation of immunosuppressed patients with nonspecific pulmonary diseases.

 

Downloads

Download data is not yet available.

Published

2009-08-04

How to Cite

1.
Dora JM, Geib G, de-Paris F, Machado AB, Furlanetto TW, de Souza CFM, dos Santos RP. Diagnosis of Disseminated Toxoplasmosis by Bronchoalveolar Lavage PCR in a Patient with AIDS. Clin Biomed Res [Internet]. 2009Aug.4 [cited 2022May29];29(2). Available from: https://www.seer.ufrgs.br/index.php/hcpa/article/view/6937

Issue

Section

Case Report